Nathan Redmond put the hosts in front early with an exquisite individual effort, cutting in from the left flank and curling a shot that took a slight deflection off Liverpool’s James Milner ball past Allison.

Liverpool drew level before the half-hour, though, when Takumi Minamino crushed his near-post shot into the roof of the Southampton net after being played in on goal by Diogo Jota.

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Joel Matip scored with the unlikeliest of headers to give Liverpool the lead on 67 minutes, leaning over his defender and redirecting a deflected corner kick past Saints goalkeeper Alex McCarthy to put his team on course for the three points.

The result leaves defending champions Man City needing a win on Sunday against Aston Villa — managed by Liverpool legend Steven Gerrard — to ensure a fourth Premier League title under Pep Guardiola.

Should City lose or draw, though, the door would be open for Liverpool, who were 14 points behind in the table on Jan. 15, to take over first on the final matchday of the season with a win over Wolves at Anfield.

Liverpool also have a Champions League final against Real Madrid on May 28 in Paris to contend with as their hopes of ending the season with four major trophies remains alive.